Isabelle Jégouzo started her career as a deputy public prosecutor at the Rouen Court of justice (1989-1991).

She then held a number of inter-ministerial positions, as well as European responsibilities, and developed a particular expertise in issues relating to international judicial cooperation.

Starting out as an advisor at France's Permanent Representation to the European Union in Brussels from 2002 to 2003, she then joined the European Commission and in particular the Anti-Fraud Office (OLAF), where she directed the Fraud and Corruption Prevention Unit.

Isabelle Jégouzo has also held the position of Deputy Secretary-General at the Secretariat General for European Affairs (SGAE) since October 2012.

From 2016 to 2019, she was Head of the Representation of European Commission in France.

Since July 2020, she has been the European and International Affairs Advisor in the Cabinet of Mr Eric Dupond-Moretti, « Garde des Sceaux », French Minister of Justice.

Appointed by decree of the President of the French Republic, Isabelle Jegouzo took up her position as Director of the French Anti-Corruption Agency in July 2023.